Segregation And Discrimination In Texas Essays - Reconstruction Era

Segregation And Discrimination In Texas Segregation and Discrimination that effected Black Texans and Mexican Americans in Texas Historians have described the early twentieth century as the nadir of race relations in this country. Ironically, populism, which tried to create a biracial political coalition, helped to encourage segregation in the south. Attempting to prevent any coalition of blacks and poor white farmers, establishment Democratic politicians frequently demonstrated their Negrophobia by accusing blacks of having inherently inferior racial characteristics and warning that such innate flaws threatened society. There began a move to make African Americans outsiders, governed by political leaders for whom they could not vote and segregated by law and custom into a separate society. The movement largely succeeded. In rural areas of Texas, most blacks did not vote, as they became victims of all white primaries. As black Texans migrated to cities, however, they acquired some voting power. Excluded from political participation, black Texans watched as white officials segregated public facilities. The state legislature in 1910 and 1911 ordained that railroad stations must have separate waiting rooms and separate water fountains and restrooms existed at public facilities. It was virtually impossible for the black citizens to stay at major hotels; to eat in better restaurants, to attend most cultural or other entertainment events unless segregated, inferior seating sections were provided. Vigilante style violence as well as law enforcement agencies upheld the separate and unequal society. Texas ranked third nationally in lynching, as mobs killed over 100 blacks between 1900 and 1910. In 1916, race riots erupted periodically throughout the period. White prejudice included animosity toward black troops in the U.S. Army. Brownville whites objected to the stationing of the all black Twenty fifth Infantry at Fort Brown. They charged that the troops raided the city in 1906 in protest of discriminatory practices. Later evidence demonstrated the unfairness of the charges, but by that time President Theodore Roosevelt had dishonorably discharged 160 of the troops. Black soldiers resentment of segregation flamed into a clash with white citizens in 1917 in Houston. Without recourse to political power, blacks in Texas, as in the rest of the nation, often chose both accommodation and resistance to segregation. The National Association for the Advancement of Colored People (NAACP) founded a chapter in 1912 in Houston, and by 1930 it had organized thirty others in the state. A Texas committee on interracial violence organized in1928 to fight extra legal acts against blacks. By then both the Dallas Morning news and the San Antonio Express had condemned lynchings. The Association of Southern Women for the Prevention of Lynching, led by Jessie Daniel Ames of Texas, mobilized strong moral opposition to violence during the 1930s. By then, most church organizations and Congressman Maury Maverick of San Antonio, who later supported a federal antilynching law, were on record as opposing racial violence. In 1942 last lynching in Texas took place. The majority of blacks stayed in rural areas, where they worked as tenants and farm laborers. As cotton prices fell, their chances to acquire their own farms decreased. Some turned to the Farmer's Improvement Society, organized by R.L. Smith in the 1890s. A Colored Farmers Educational and Cooperative Union was founded in Dallas in 1905. Other organizations established farmers' institutes and local cooperative associations. These organizations all spoke of accommodation and self help to counteract poverty and segregation. But rural Texans remained poor, and black poverty exceeded that of most whites. Marcus Garvey, a Jamaican and the organizer of the Universal Negro Association, advocated black pride, a back-to-Africa movement, and the development of black enterprises. His attempt to found a local chapter in Dallas in 1922 met with opposition, as did the efforts of Sam, from many black leaders and middle-class African Americans. The expanding economy of the 1920s did open new employment opportunities for black males as porters and chauffeurs and in building trades and oil refining. Except as janitors and laborers, the public sector hired few African Americans. The segregated communities produced a small black bourgeoisie. Ministers and teachers composed the largest occupational group of black professionals in 1930. The number of black undertakers went from 1 in 1900 to 198 in 1929, and they joined the black bourgeoisie of the period. Most black Texans lacked financial

Captain vs. Master

Captain vs. Master Captain vs. Master Captain vs. Master By Mark Nichol What’s the difference between a ship’s captain and a ship’s master? In contemporary usage, not much, but historically, the titles represented quite distinct roles. Captain is more common in modern usage, but master is more historically accurate. Captain derives ultimately from the Latin term caput, meaning â€Å"head† and related to other words beginning with cap- such as capital; capitaneus, meaning â€Å"chief,† and the French word capitaine, meaning â€Å"leader,† are the intermediate forms. Master, originating in the Latin word magis, meaning â€Å"more,† stems from magister, which also means â€Å"chief† as well as â€Å"director† or teacher.† In the Middle Ages, the man in charge of a ship, often but not always the owner, was called the master; this usage stems from imperial Rome. On the high seas, where delay or dissension could lead to destruction and death, the master had absolute authority, hence the title. However, before the advent of standing navies, civilian ships were often offered or impressed for use in transporting soldiers and their supplies from one place to another. When the captain of a company of soldiers brought the troops aboard for transport, he assumed military command of the ship, determining its destination and, if the ship engaged in hostilities at sea, directing the battle. In matters of sailing and maneuvering, though, the captain deferred to the master, who of course remained on board. (Before captain became a specific military rank, it designated a leader of roughly up to several hundred soldiers assembled for a specific battle or campaign. Much later, it became an official designation for a standing military unit of a circumscribed similar size.) As civilian ships were given long-term military roles, this division of responsibilities remained in effect: A captain had overall authority, but the master was responsibility for sailing operations. When permanent navies were established, roughly coincident with the establishment of standing armies, captain became a precise military rank in both settings. Master was also codified as the label for a specific posting; the master (sometimes called the sailing master) oversaw navigation and provisioning of the ship under direction of the captain, who by this time was a skilled mariner as well as a military leader. Naval captains and those commanding land-based units were and are not equivalent in rank: The largest ships in the Age of Sail eventually carried a thousand or more crew members, and ships often operated independently, requiring the captain to exercise great responsibility (and life-or-death authority), whereas an army captain commanded no more than a couple hundred men and was part of a more restrictive chain of command. Therefore, to this day, a navy captain holds a fairly high status in the naval hierarchy, whereas an army captain (or an officer with the equivalent rank in an air force or in the marines) has a comparatively minor role, though he or she must still demonstrate leadership skills. Even in the Middle Ages, a captain designated one or more lieutenants to assist him with command, to lead the company if he was absent or incapacitated, or to temporarily take responsibility for part of the unit. (The word lieutenant comes from the French phrase lieu tenant, meaning â€Å"deputy,† from words meaning â€Å"place† and â€Å"holder.†) Later, a ship was assigned one or more lieutenants depending on the size of the vessel. Meanwhile, master also briefly became a naval military rank below the rank of lieutenant, rather than a position, but it was phased out as naval vessels were increasingly powered by steam rather than sail. Other words that apply to naval command include commander, from an Old French word meaning â€Å"one who commands.† (The rank was originally styled â€Å"master and commander† to denote the commanding officer of a small vessel who doubled as the master, hence the Patrick O’Brian novel of that title and the related film starring Russell Crowe.) Commodore, the Dutch word derived from this term, came to apply to a captain given temporary command of a group of vessels and later became a specific rank above that of captain. (The similar term commandant is not a rank; it applies to an officer of any rank who commands a training facility or a prison.) Admiral, meanwhile, referring to a high-ranking naval officer in command of an entire navy or a fleet or major unit within one or the other, is from the Arabic word amir, meaning â€Å"military commander† (the source of emir, a modern word for an Arab leader) and, like captain, originally pertained to a land-based leader before it was applied to one who leads naval operations. On many modern civilian ships, the person in charge is officially referred to as the captain, whether or not there is a command hierarchy more or less based on naval tradition, though master is also common. In popular usage, however, captain came to prevail over master, so that, even now, the owner of a small pleasure craft will be referred to as â€Å"Captain† or â€Å"Skipper†; the latter word is derived from the Dutch word scipper, meaning â€Å"operator of a ship.† Skipper is also used formally to refer to the master of a small vessel such as a tugboat. Captain is used in other civilian command hierarchies, as in police and fire departments and the like, as well as to refer to the acknowledged leading athlete on a sports team, but master has not been adopted in such contexts from nautical usage. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Misused Words category, check our popular posts, or choose a related post below:Masters Degree or Master's Degree?"Latter," not "Ladder"The Difference Between "Phonics" and "Phonetics"

Communication Portfolio Essay Example | Topics and Well Written Essays - 750 words

Communication Portfolio - Essay Example I also appreciate the lessons that I learned in the lectures about the CCCD Model of Communication because it taught me to become persuasive and to communicate well. Having gone through the course, I believe that my goals and objectives had changed for the better. Before the class started, I must admit that I share most of student’s perspective to at least pass the subject and hopefully, to do well. This goal changed with the perspective and insight that I learned from the class. I believe I am now more â€Å"professionally oriented† because I now look forward on getting my dream job and to get that, I have to prepare as early as now. My former mindset of just passing the subject has changed from actually learning it and set small achievable goals that can lead to achieving my bigger goals. Goals also do progression and we just do not achieve bigger goals immediately. We have to accustom ourselves in setting smaller goals and achieving it and it helps to actually write them down because it felt like we are committed to them. There are few lessons that I would like bring up in this paper because it resonated in me or left a lasting impression. It is about the lesson in conscious communication and interviewing. This chapter is important to me because I used to dread interviews, presentation and being â€Å"interrogated by serious people†. But I realize that to get the job that I dreamed of, I have to handle if not master interviews and overcome my fear of it. And the course indeed helped me overcome my fear about interviews. It did sonot by telling me not to fear it but rather on understanding its dynamics and providing me the tools to be effective at it. I learned that interviews vary and not just those â€Å"scary ones† and each type of them has different type of interactions of which the course taught me. I am glad however that I am provided with the tools to overcome my anxiety with interviews and succeed with it by using the CCCD model for interview which set the parameters for the interview that taught me the steps to become effective at it. It made me realize the common mistakes committed during interviews and by realizing it, taught me to avoid it and not to commit the same mistake. I believe that this knowledge and skills I learned from the course such as the CCCD model for interviewing will be invaluable in getting my dream job in a very prestigious company. I can simplify what I learned from this CCCD model of interview as setting the goal for interview, how to deliver during interview and to practice it. Learning this tools made me more confident about myself and my goal has inadvertently changed as I gain more confidence. Now my goal is to realize my dream of getting into a prestigious company and working my dream job that is related to communication. I am aware that I still have a lot to learn to realize my goal but knowing the essence and foundation is essential for my future growth. From now on, I will consciously practice what I learned from CCCD to make it an inherent skill. Practice makes it perfect and I want this skill to become my nature so I have to practice it. I also have to equip myself with knowledge and ski

Analysis over a piece of art work Essay Example | Topics and Well Written Essays - 500 words

Analysis over a piece of art work - Essay Example earlier, all the elephants died in battle and naming the artwork after the general who thought of using the huge animals is an evident attempt of the artist to link her work to such cause. The sculptor used acrylic and glaze on metal, making the colors used come alive as they have an initial effect of catching the attention of viewers. An elephant could probably be of no meaning to anyone and might just be noticed by animal lovers like me however, Tovar’s Hannibal also presents a mysterious message that calls the audience to ponder about why it was created. Naturally, elephants have only one color but Tovar’s elephant has multiple colors mixed all over the body of the image which could be interpreted by viewers in a variety of ways. For me, I think this variation of colors tells that the advocacy communicated through the artwork is true regardless of where the elephants are located, whether in Italy, Africa, Asia or America. Moreover, it could also refer to whatever use the elephants are employed, whether in wars, zoos, or slaughtered for their ivories, their preservation should always be made a priority. Elephants are wonderful animals which are popular for their treasured tusks, strength and enormous size and their number is decreasing by the year because of irresponsible killings. Hannibal seems to tell people, ‘Hey, look at what you will lose if you keep killing us’. Tovar’s artwork is a freestanding sculpture in an open form that interacts with the spaces around it. This gives an unspoken message of ‘leave me alone’, believed to be related to the theme of the art. This and the vibrant colors of Hannibal plead humans to allow such beautiful creations live among people, in their natural habitat so that they may also enjoy the beauty of life. It could probably be impossible to say that we do not enjoy or appreciate the existence of elephants because they sure help humans in many ways and they are even made as pets in some countries. Therefore, as

Applied economics Essay Example | Topics and Well Written Essays - 1000 words

Applied economics - Essay Example ucted to establish the functions of human capital earnings and its impacts on the decomposition of the periodic earnings into linear function forms, in which the log of earnings serve as both the function of schooling measure in terms of years of experience in work and other factors representing heterogeneity within a cross-section sample of people observed, and dependent variables. This simple statistical model has however been faced by some limitations, i.e., biasness in the estimation of returns to education and endogeneity in the schooling variables. As a positively correlated function of the unobserved variable of ability, people with varied ability to work and learn are in most instances a better position to school for longer periods; hence this enhanced ability will have a reflection of higher wages within their occupations. Additionally, existence of a symmetric correlation between any of the independent variables such as schooling and the error term in an OLS regression can consequently lead to bias in the estimates. In this case, effects of ability/heterogeneity have to be random in the sample to avoid positive correlations. Card (1999) explored the causal relationship of education on earnings, and explicitly the study analysed the heterogeneity between schooling of twins in contrast to their earnings. The assumption in the study was that twins would have the same ability and other external influences so that differences in wages could be more accurately associated with differences in education. Card used the pooled sample of men and women standing up to 198,075 aged from 16 – 66 during the years 1994 to 1996. In this given time frame, the study targeted the differences between individuals having 10, 12 and 16 years of schooling to their returns. An OLS regression analysis was used to inspect the human capital earning with variety of hourly, weekly and annual earnings. The study findings explored an interesting impact of an instrumental factor family

Development of Anti-Cancer Agent

Development of Anti-Cancer Agent Design, ultrasound assisted synthesis and in-vitro anticancer activity of 3-(4-chlorophenyl) sydnone and 3-(4-chlorophenyl) sydnonecarboxaldehyde against 60 Human Tumor cell lines Sachin K. Bhosale, Shreenivas R. Deshpande  and Rajendra D. Wagh Design, ultrasound asisted synthesis and in-vitro anticancer activity of 3-(4-chlorophenyl) sydnone and 3-(4-chlorophenyl) sydnonecarboxaldehyde against 60 Human Tumor cell lines Abstract: In an attempt to develop an effective and safer anticancer agent, 3-(4-chlorophenyl)-4-sydnonecarboxaldehyde 5 have been designed and synthesized under ultrasonication by formylation of 3-(4-chlorophenyl)-sydnone 4 and characterized by spectral studies. The ultrasonic method of synthesis was found to be simple, ecofriendly, reduces reaction time and gave good yield when compared with traditional methods of synthesis. Anticancer activity of the compounds were tested against 60 human tumor cell lines and compared with standard drug Vincristine sulphate. Cytotoxicity evaluation revealed that compound 5 is most potent against NCI-H23 (Non-Small cell lung cancer) with comparative activity of Vincristine sulphate. Compound 5 also had shown moderate cytotoxicity against T-47D (Breast cancer), CAKI-1, UO-31 (Renal cancer), HL-16TB (Leukemia), NCI-H23, NCI-H522 (Non-Small cell lung cancer), SNB-75 (CNS cancer), MALME-3 (Melanoma). In future, research and modification of compounds to different derivatives may lead to development of potent anticancer drug. Keywords: Anticancer, 1, 2, 3-oxadiazol-5-olate, Formylation, Ultrasonication INTRODUCTION Mesoionic sydnone compounds have shown a variety of biological activities including antitumor ((Kier et al., 1964, Dunkley et al., 2003, Satyanarayana et al., 1995, Kavali et al., 2000, Dunkley et al., 2003, Fregly et al., 1964, Stewart et al., 1965, Roche et al., 1965). It is thought that the ionic resonance structures of the heterocyclic ring promote significant interactions with biological molecules. In 1992 a series of 4-substituted-3-nitrophenylsydnones were synthesized and evaluated by Grynberg et al for anticancer activity and it was found that the 4-chloro and the 4-pyrrolidino compounds significantly enhanced the survival of Sarcoma 180 (S180), Ehrlich carcinoma (Ehrlich) and Fibrous histiocytoma (B10MCII) tumor bearing mice(Dunkley et al., 2003). It was also found that the larger hetero rings; p-piperidino and p-morpholino, were less potent (Kier et al., 1964, Dunkley et al., 2003). Herein we report the design, synthesis, and biological evaluation of two para-chloro substit uted analogues of sudnone molecules 4 and 5. These were tested for 60 human tumor cell lines at the National Cancer Institute for antitumor activity at a minimum of five concentrations at 10-fold dilutions.The synthesized chloro substituted sydnones (4 and 5) passed the primary assay by inhibiting the growth of at least one cell line to less than 32%, and both are proved to be moderate active and versatile against each cell line. MATERIALS AND METHODS All chemicals and reagents were purchased form from Sigma-Aldrich, Mumbai, India. Melting points of the intermediates and the final products were recorded using a Systolic melting point apparatus and are reported uncorrected. Thin layer chromatographies (TLC) were performed on E-Merck precoated 60 F254 plates and the spots were rendered visible by exposing to UV light. Infra red spectra were recorded in KBr discs using Jasco FTIR 1460 Plus spectrometer. NMR spectra were obtained on a BRUKER AVANCE II 400 NMR spectrometer at 500 MHz for 1H and 125 MHz for 13C, the chemical shifts are expressed in ÃŽ ´ (ppm) downfield from tetramethylsilane (TMS). Electron impact mass spectra were recorded on WATERS, Q-TOF MICROMASS (LC-MS) instrument. Elemental analyses (C, H, N) were in full agreement with the proposed structures within  ±0.4% of the theoretical values. The ultrasonic irradiation was performed by using a Biotechnics India TM ultrasonic cleaner bath, model 1510, AC input 115 V, outp ut 50 W, 1.9 liters with a mechanical timer (60 min with continuous hold) and heater switch, 47 KHz. Synthesis of Ethyl N-(4-chlorophenyl) glycinate (1) A mixture of Para-Chloroaniline (2.80 g, 0.02mol) and chloroethyl acetate (2.12 mL, 0.02mol) was added to the solution of ethanol (20 mL) and anhydrous sodium acetate (3.28 g, 0.04mol) under ultrasonication conditions and allowed to react for 120 min. The mixture was diluted with 20 mL of water and cooled in refrigerator for overnight and recrystallized in ethanol to yield 1 (83%), mp 114-116  ºC. IR (KBr): 3327, 2950, 2934, 2879, 1756, 1069; 1H NMR (400 MHz, DMSO-d6): ÃŽ ´ 1.21 (t, 3H, COOCH2CH3), 3.76 (s, 1H, NH), 4.29 (s, 2H, CH2), 4.54 (q, 2H, COOCH2CH3), 6.83-7.21 (m, 4H, Ar-H); 13C NMR (40 MHz, DMSO-d6): ÃŽ ´ 14.65, 44.73, 62.07, 115.12, 123.22, 129.01, 146.26, 173.13. Synthesis of N-(4-chlorophenyl) glycine (2) Ethyl N-(4-chlorophenyl) glycinate (4.26 g, 0.02mol) and sodium hydroxide (1.2 g, 0.030mol) in ethanol was heated under ultrasonication conditions at 65  °C for 15 min and allowed to cool and acidified with dil HCl. Yield 87 %, mp 146-148  ºC. IR (KBr): 3319, 3277, 2951, 2937, 2879, 1703, 1063; 1H NMR (400 MHz, DMSO-d6): ÃŽ ´ 4.29 (s, 2H, CH2), 6.39 (s, 1H, COOH), 6.55 (s, 1H, NH), 6.79-7.27 (m, 4H, Ar-H); 13C NMR (40 MHz, DMSO-d6): ÃŽ ´ 44.48, 115.02, 124.16, 130.02, 145.97, 171.98. Synthesis of N-nitroso (4-chlorophenyl) glycine (3) Ice cold solution of the N-(4-chlorophenyl) glycine (3.72 g, 0.02mol) was added in crushed ice water (40 mL). A solution of sodium nitrite (1.38 g, 0.02mol) in ice cold water (10 mL) was added dropwise under ultrasonication condition at 0  °C for 10 min. The reaction mixture was filtered and precipitated by adding concentrated hydrochloric acid to the filtrate. Precipitate was filtered and recrystallized in methanol to yield 3 (81%), mp 109-111  ºC. IR (KBr): 3255-2521, 2923, 2849, 1711, 1569, 1325, 1062; 1H NMR (400 MHz, DMSO-d6): ÃŽ ´ 5.02 (s, 2H, CH2), 6.93-7.45 (m, 4H, Ar-H), 11.55 (s, 1H, COOH); 13C NMR (40 MHz, DMSO-d6): ÃŽ ´ 49.42, 120.75, 128.29, 130.43, 138.78, and 169.25. Synthesis of 3-(4-chlorophenyl) sydnone (4) Acetic anhydride (30 mL) was added to 3 (5.40 g, 0.0252 mol) under ultrasonication condition at room temperature for 60 min. The reaction mixture was left overnightat room temperature. The solution was poured slowly into cold water which was very well stirred. The crude sydnone was filtered, dried and recrystallized in ethanol to yield 4 (93%), mp 139-141  ºC. IR (KBr): 3181, 1748, 1053. 1H NMR (400 MHz, DMSO-d6): ÃŽ ´ 7.23 (s, 1H, sydnone), 7.49-8.13 (m, 4H, Ar-H). 13C NMR (40 MHz, DMSO-d6): ÃŽ ´ 123.15, 126.49, 131.53, 136.13, 141.13, 170.07 Synthesis of 3-(4-chlorophenyl)-4-sydnonecarboxaldehyde (5) N-Methylformanilide 2.84g (0.0210mol) and phosphoryl chloride (3.17g, 0.0205mol) were mixed under ultrasonication conditions for 10 min. After 0.5 h, 3.0 g (0.0186mol) of 4 was added portionwise with swirling and cooling under ultrasonication below 350C. Hydrogen chloride was evolved vigorously. After standing overnight, the viscous, dark-brown mixture was dissolved in 15 ml. of acetone and poured (stirring) into 75 ml. of ice water. The yellow-orange precipitate was filtered, washed (cold water), and dried. Yield 56%, mp 75-77 0C. MS (M+) (m/e) 223.99, 225.996, 225.002. IR (KBr): 1790 (Ñ ´C=O sydnone ring), 1640 (Ñ ´C=O aldehyde). 1H NMR (400 MHz, DMSO-d6): ÃŽ ´ 7.2, 7.2, 7.3, 7.3 (Cl-Ph-), 9.61 (Sydnone-4-CHO). 13C NMR (40 MHz, DMSO-d6): ÃŽ ´ 127, 129, 129, 130, 130, 134 (Cl-Ph-) 190 (CHO). Element analysis: C; 48.13, H; 2.24, N; 12.47, O; 21.37 Scheme 1-Synthesis of 3-(substituted aryl)-4-sydnonecarboxaldehyde (5) under ultrasonication conditions 1.3. Anticancer screening The synthesized compound was screened for preliminary anticancer assay by National Cancer Institute (NCI), Bethesda, USA in an in vitro 60 human tumor cell panel. The process utilized 60 different human tumor cell lines of the leukemia, Non-small cell lung, Colon, CNS, melanoma, ovarian, renal, Prostrate and breast cancers which was aimed in showing selective growth inhibition or cell killing of particular tumor cell lines by specific compound. The screening begins with the evaluation of selected compounds against these 60 cell lines at a single dose of 10-5 M. The output from the single dose screen is reported as a mean graph of the percent growth of treated cells. It allows detection of both growth inhibition (values between 0 and 100) and lethality (values less than 0) (Roschke et al., 2003, Lorenzi et al., 2009, Mingyi et al., 2013, Al-Suwaidan et al., 2013, Senff-Ribeiro et al., 2004, Butkovic et al., 2011, Lorenzi et al., 2009, Mingyi et al., 2013, Al-Suwaidan et al., 2013, Sen ff-Ribeiro et al., 2004, Butkovic et al., 2011). RESULT Compund 5 showed highly cytotoxic activity against NCI-H23 cell line (Non-Small cell lung cancer) as compared to standard drug Vincristine sulphate. Compound 5 also had shown moderate cytotoxicity against T-47D (Breast cancer), CAKI-1, UO-31(Renal cancer), HL-16TB (Leukemia), NCI-H23, NCI-H522 (Non-Small cell lung cancer), SNB-75 (CNS cancer), MALME-3 (Melanoma). Details of % growth inhibition for comp. 4 (NSC 35759) 5 (NSC 774943/1) as shown in table 1. Table1 One dose mean graph for compound 4 (NSC: 35759) and compound 5 (NSC: 774943 / 1) Conc: 1.00E-5 Molar Table 2 Percent Growth inhibition of synthesized compounds against most effective cancer cell lines Figure1 Percentage growh inhibition for cytotoxic activity evaluation of synthesized ompounds Figure 2 Percentage growh inhibitions for cytotoxic activity evaluation of compound 4 Figure 3 Percentage growh inhibitions for cytotoxic activity evaluation of compound 5 Figure 4 Percentage growh inhibitions for cytotoxic activity evaluation of standard anticancer drug Vincristine sulphate. DISCUSSION Molecules synthesized under ultrasonication conditions. The method provides several advantages over current reaction methodologies, including a simple work up procedure. The ultrasonic method of synthesis was also found to be simple, ecofriendly, reduces reaction time and gave good yield when compared with traditional methods of synthesis. Cytotoxicity evaluation revealed that out of 60 human tumor cell lines, compound 5 is highly effective against SNB-75 (CNS cancer) and UO-31 (Renal cancer) human tumor cell lines.Compund 5 showed highly cytotoxic activity against NCI-H23 cell line (Non-Small cell lung cancer) as compared to standard drug Vincristine sulphate. Compound 5 also had shown moderate cytotoxicity against T-47D (Breast cancer), CAKI-1, UO-31(Renal cancer), HL-16TB (Leukemia), NCI-H23, NCI-H522 (Non-Small cell lung cancer), SNB-75 (CNS cancer), MALME-3 (Melanoma). CONCLUSION In the process of anticancer drug discovery, to find new potential anti-lung cancer agent, we designed and synthesized molecule 5. As compund 5 showed highly cytotoxicity against NCI-H23 cell line (Non-Small cell lung cancer) in comparision to standard drug Vincristine sulphate, in future, research and development with designing desired modifications of molecule 4 and 5 may develop in safer and effective potential anticancer molecules. ACKNOWLEDGEMENT Authors are thankful to BCUD, University of Pune, INDIA (Project-13PHM000018) for financial assistance, NCI, USA for carrying out anticancer activity, SAIF Punjab University for spectral study, JNTU Hyderabad and Dr. Dhake A. S., SMBT College of Pharmacy, Dhamangaon, Nasik (MS) India for providing necessary facilities to carry out the research work. COMPETING INTERESTS The authors declare that they have no competing interest. REFERENCES Kier LB, Dhawan D and Fregley MJ (1964) Synthesis of alkyl substituted sydnone carboxylic acids. J. Pharm. Sci., 53: 677. Dunkley CS and Thoman CJ (2003) Synthesis and biological evaluation of a novel phenyl substituted sydnone series as potential antitumor agents. Bioorg Med. Chem. Lett., 13(17): 2899-2901. Satyanarayana K and Rao MN (1995) Synthesis, antiinflammatory, analgesic and antipyretic testing of 4-[1-oxo-(3-substituted aryl)-2-propenyl]-3-phenylsydnones and of 3-[4-[3-(substituted aryl)-1-oxo-2-propenyl] phenyl] sydnone J. Pharm. Sci., 84(2):263-6. Kavali JR and Badami BV (2000) 1, 5-Benzodiazepine derivatives of 3-arylsydnones: synthesis and antimicrobial activity of 3-aryl-4-[2†²-aryl-2†², 4†², 6†², 7†²-tetrahydro-(1†²H)-1†², 5†²-benzodiazepine-4†²-yl] sydnones. IL Farmaco, 55: 406-409. Fregly MJ, Kier LB and Dhawan D (1964) Chloruretic, naturetic and depressor activities of some substituted sydnones. Tox Appl. Pharmacol., 6:529 Stewart TG and Kier LB (1965) Synthesis of several mesoionic 1, 3,4-thiadiazoles. J. Pharm. Sci., 54:731. Roche EB and Kier LB (1965) Synthesis of two 4,5- Dialkylsydnone J Pharm. Sci., 54: 1700. Dunkley CS and Thoman CJ (2003) Synthesis and biological evaluation of a novel phenyl substituted sydnone series (VII) as potential antitumor agents. ChemInform, 34:129. Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE and Sellers WR (2005). Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature, 436 (7047):117-122. Adams S, Robbins FM, Chen D, Wagage D, Holbeck SL, Morse HC 3rd, Stroncek D and Marincola FM (2005). HLA class I and II genotype of the NCI-60 cell lines. J. Transl. Med., 3(1):11. Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, Lababidi S, Scudiero DA, Weinstein JN and Kirsch IR (2003) Karyotypic complexity of the NCI-60 drug screening panel. Cancer Res, 63(24):8634-8647. Lorenzi PL, Reinhold WC, Varma S, Hutchinson AA, Pommier Y, Chanock SJ, Weinstein JN (2009) DNA Fingerprinting of the NCI 60 cell line panel. Mol. Cancer Ther, 8(4):713-24. Mingyi M, Longru S and LouMei Ji (2013) Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3-O-substituted carbonic ether moiety as potential antitumor agents. Chemistry Central Journal, 7(1):179. Al-Suwaidan IA, Alanazi AM Abdel-Aziz AA, Mohamed MA and El-Azab AS (2013). Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: Molecular docking study. Bioorganic medicinal chemistry letters, 23:3935-3941. Senff-Ribeiro A, Echevarria A, Silva EF, Franco CRC, Veiga SS and Oliveira MBM (2004) Cytotoxic effect of a new 1, 3, 4-thiadiazolium mesoionic compound (MI-D) on cell lines of human melanoma. Br. J. Cancer; 91(2): 297–304. Butkovic K, Marinic Z and Sindler-Kulyka M (2011) Synthesis of 3-(o-stilbenyl) sydnone and 3-(o-stilbenyl)-4-substitutedsydnone derivatives and their antitumor evaluation. ARKIVOC, 1:15

A Mothers dream Essay -- essays research papers

A Mother's Dream For a lot children growing up, our mothers have been an complete part of what made us who we are. Mostly all good mothers want the best for their child and they are determine to do whatever it takes for them to get it. The central struggle in Amy Tan's story ‘‘Two Kinds'' is a battle of wills between the narrator, a young Chinese-American girl, and her mother, a Chinese immigrant. "Two Kinds'' is a coming-of-age story, in which the narrator, Jing-mei, struggles to forge her own sense of identity in the face of her strong-willed mother's dream that she become a "prodigy.'' Suyuan, Jing-mei's mother, believes in the American Dream. With hard work, she feels that Jing-Mei can be anything she wants to be in this great country. After all, Suyuan does not want her daughter to ever suffer the kind of deprivation and tragedies that she had to endure in China. But Jing-Mei has no desire to prove herself or excel in any field. She wants to take life as it comes. In her words, â€Å"I did not believe I could be anything I wanted to be. I could only be me† Tan (679). Since Suyuan believes that anything can be accomplished and she uses her daughter as her outlet to prove it. She continuously gives Jing-mei numerous test and eventually forces her to take piano lessons, which becomes Suyuan's prime focus of her 'perfect dau...